Trifluoropyrazine is one of the important herbicides recently launched by BASF, widely used in field crops, fruit trees, non-agricultural fields, etc., to control broad-leaved weeds and grasses. It is a new member of BASF's pre seedling herbicide product portfolio. The listing of trifluoroxazine will further enhance the company's position in the global herbicide market.

Mechanism of action and application

Trifludomoxazin (commonly known as trifludimoxazin; development code: BAS 850 H; trade names: Tirexor, Vulcarus, etc.) is a triazine ketone herbicide developed by BASF and publicly disclosed in 2014.

Trifluoropyrazine is a type of herbicide that inhibits protoporphyrinogen oxidase (PPO), and is classified as Group 14 by the International Action Committee on Herbicide Resistance.

Trifluoropyrazine has contact killing, quick acting, and sustained effects, which can be quickly absorbed by the roots and leaves of plants. By inhibiting PPO, it damages the cell membrane, leading to weed death. After application, sensitive weeds that have been unearthed will show symptoms of chlorosis and necrosis within a few hours, and the weeds will die within 3-5 days; Sensitive weeds that are about to be unearthed will die shortly after reaching the soil surface or being unearthed.

Trifluperazine is mainly used in cereals, corn, soybeans, peanuts, vegetables, fruit trees and non crop fields to prevent and control gramineous weeds and broad-leaved weeds such as ryegrass, chenopodium album, ragweed, kentucky bluegrass, foxtail grass, sinew grass, fan weed, reverse branch amaranth, purslane, theophrasti theophrasti, fern, various self-produced rape, wild mustard, etc. This product is both a PPO inhibitor and can control PPO resistant weeds, including difficult to treat resistant weeds such as Amaranth and Ambrosia, making it an important resistance management tool. Trifluoropyrazine can also prevent and inhibit the secondary occurrence of these weeds. Used before sowing, before seedling, and after seedling.

BASF pointed out that trifluoroxazine is the first herbicide in nearly 20 years to have a novel mechanism of action in controlling grass weeds through foliar contact, providing a new tool for preventing ryegrass before crop planting.

In order to expand the spectrum of prevention and control, BASF has developed a compound product of trifluoperazine and bensulfuron, which has a synergistic effect between the two; Trifluoropyrazine can also be mixed with glyphosate barrels to further expand the prevention and control spectrum. According to reports, trifluoroxazine may be used in BASF's currently developing herbicide trait system that is resistant to PPO inhibitors.

The review results of the US Environmental Protection Agency (EPA) indicate that trifluoroxazine poses no risk to human health, but it is recommended to take certain measures to reduce ecological and resistance risks.

Registration and listing

Trifluoropyrazine was the first to be registered in Australia, and subsequently obtained registration in countries such as Canada and the United States. BASF has also submitted registration applications to multiple countries in Asia, the Americas, and other regions.

(1) Australia

On May 28, 2020, the Australian Pesticides and Veterinary Medicines Administration (APVMA) approved the registration of BASF's trifluoperazine raw material; On July 1, 2020, BASF's compound product Voraxor (trifluoperazine+bensulfuron) based on trifluoperazine was approved for registration in Australia. This is the first registration of trifluoroxazine worldwide. Listed in the country in 2021.

(2) Canada

On January 21, 2021, BASF's 99.2% trifluoperazine raw material, Vulcarus ™ (Trifluoropyrazine), Voraxor ™ (Trifluazuron+benzimidacloprid) registered in Canada; On August 10, 2021, BASF's large packaging product Voraxor ™ Bulk (trifluoroxazine+bensulfuron) has been approved for registration in Canada.

(3) United States

On May 25, 2021, BASF's 99.2% trifluoperazine raw material and formulation product Tirexor (trifluoperazine) was registered in the United States. Tirexor is used for field crops (corn, vegetables, peanuts, small grains, soybeans, etc.), fruit trees, non-agricultural fields, etc. It is applied before or after seedlings to control broad-leaved weeds and grasses.

Compound patents

Trifluoropyrazine is a patented product, and BASF Europe has applied for compound patents from its PCT, Europe, the United States, and China; The name of the invention is: Herbicidal Benzoxazinines (Herbicidal Benzoxazinone). Its PCT patent (WO2010145992), European patent (EP2443102A1), and Chinese patent (CN102459205A) were all filed on June 11, 2010, and will expire on June 10, 2030; US Patent (US2012100991) filed on June 11, 2010 and June 11, 2030